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KMID : 1123920040180061821
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 6 p.1821 ~ p.1824
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Effects of Radix Achyranthis Bidentatae Extract on Proliferation and Differentiation in Human Osteoblast-like Cells
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Seo Eun-A
Moon Hyung-Chul
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Abstract
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In order to investigate the effects of Radix Achyranthis Bidentatae (RAB) on the growth and differentiation of human osteoblast-like cells, we supplemented the culture medium of MG-63 cells with various concentrations of RAB water extracts. RAB extracts significantly stimulated cell growth, as confirmed by the colorimetric MTT (3-dimethylthiazol-2,5-diphenyltetrazolium bromide) assay. RAB extracts also increased the alkaline phosphatase (ALP) activity, which is a osteoblast differentiation marker. These results suggest that RAB can stimulate osteoblastic activity and may represent new pharmacological tools for the treatment of osteoporosis.
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KEYWORD
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Radix Achyranthis Bidentatae, human osteoblast-like cell, alkaline phosphatase, osteoporosis
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